Serious Reactions with Tramadol: Seizures and Serotonin Syndrome

Serious Reactions with Tramadol: Seizures and Serotonin Syndrome

Toxicology was significant for opioids and negative for benzodiazepines. The table below shows side effects after Flexeril and Ambien administration in recommendable doses. The incidence can be significantly increased if these drugs are overdosed or taken together. This can lead to a drug interaction between Tramadol and cyclobenzaprine, increased sedation, respiratory depression, or other dangerous side effects. No, you should NOT take Tramadol and Flexeril together, unless specifically directed by your doctor.

  • Otherwise, she was alert and had no respiratory difficulties.
  • In this study cyclobenzaprine (10mg/d) failed to significantly improve sleep in the short term but this may have been due to the relatively low dose employed.
  • Studies in women breastfeeding have demonstrated harmful infant effects.

Some mixtures of medications can lead to serious and even fatal consequences.

Cyclobenzaprine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

If this problem continues or gets worse, check with your doctor right away. This medicine may cause sleep-related breathing problems (eg, sleep apnea, sleep-related hypoxemia). Your doctor may decrease your dose if you have sleep apnea (stop breathing for short periods during sleep) while using this medicine.

It is very important that your doctor check your or your child’s progress at regular visits, especially within the first 24 to 72 hours of treatment to make sure the medicine is working properly. Blood and urine tests may be needed to check for unwanted effects. If you think that this medicine is not working as well after you have been taking it for a few weeks, do not increase the dose.

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Do not use this medicine if you are using or have used an MAO inhibitor (MAOI) such as isocarboxazid [Marplan®], linezolid [Zyvox®], phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]) within the past 14 days. If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Qdolo should not be used in children younger than 12 years of age and to relieve pain after surgery (eg, surgery to remove adenoid or tonsil) in children. Do not take more of it and do not take it more often than your doctor ordered.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Chronic use of opioids may cause reduced fertility; it is unknown whether these effects are reversible. A long-acting formulation of cyclobenzaprine has been introduced and is believed by some clinicians to have a lower side effect profile than the immediate-release formulation of this drug. Tramadol is a generic name for an opioid narcotic-like pain reliever that is used for relieving moderate to moderately severe acute and chronic pain.

This formulation is applied topically to the affected area and is absorbed through the skin. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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Using this medicine while you are pregnant may cause neonatal withdrawal syndrome in your newborn baby. Check with your doctor right away if your baby has an abnormal sleep pattern, diarrhea, a high-pitched cry, irritability, shakiness or tremors, weight loss, vomiting, or fails to gain weight. Tell your doctor right away if you think you are pregnant or if you plan to become pregnant while using this medicine. Appropriate studies have not been performed on the relationship of age to the effects of Ryzolt™ in children younger than 16 years of age.

Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash. Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system (CNS). The use of alcohol or other medicines can flexeril lower blood pressure that affect the CNS with tramadol may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping. Whether cyclobenzaprine is superior to other drugs for the management of acute myofascial strain is unclear and it usually adds more side effects with little therapeutic gain (Turturro et al 2003).

Other proven treatment options include physical therapy and therapeutic massage. Tramadol’s action on the opioid, serotonin, and norepinephrine receptors has an additive pain-relieving effect and is thus prescribed and dispensed for this indication. The FDA has authorized it for treating moderate to moderately severe pain, such as post-operative discomfort, or chronic conditions like arthritis. If use together is necessary, it is prudent to use the lowest dose and shortest duration necessary to achieve treatment goals. Side effects, such as sedation, respiratory depression, urinary retention, and constipation should be monitoed.

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